Influence of substance P on the behavioral changes induced by haloperidol in rats
Identifieur interne : 005210 ( Main/Exploration ); précédent : 005209; suivant : 005211Influence of substance P on the behavioral changes induced by haloperidol in rats
Auteurs : Francois B. Jolicoeur [Canada] ; Daniel B. Rondeau [Canada] ; Ferdinand Belanger [Canada] ; George Fouriezos [Canada] ; André Barbeau [Canada]Source :
- Peptides [ 0196-9781 ] ; 1980.
Abstract
Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.
Url:
DOI: 10.1016/0196-9781(80)90042-X
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001B38
- to stream Istex, to step Curation: 001B38
- to stream Istex, to step Checkpoint: 002771
- to stream Main, to step Merge: 005C24
- to stream Main, to step Curation: 005210
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Influence of substance P on the behavioral changes induced by haloperidol in rats</title><author><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="Francois B." last="Jolicoeur">Francois B. Jolicoeur</name></author><author><name sortKey="Rondeau, Daniel B" sort="Rondeau, Daniel B" uniqKey="Rondeau D" first="Daniel B." last="Rondeau">Daniel B. Rondeau</name></author><author><name sortKey="Belanger, Ferdinand" sort="Belanger, Ferdinand" uniqKey="Belanger F" first="Ferdinand" last="Belanger">Ferdinand Belanger</name></author><author><name sortKey="Fouriezos, George" sort="Fouriezos, George" uniqKey="Fouriezos G" first="George" last="Fouriezos">George Fouriezos</name></author><author><name sortKey="Barbeau, Andre" sort="Barbeau, Andre" uniqKey="Barbeau A" first="André" last="Barbeau">André Barbeau</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8329DDE00860AE8428688ABEF4A21467FA942225</idno><date when="1980" year="1980">1980</date><idno type="doi">10.1016/0196-9781(80)90042-X</idno><idno type="url">https://api-v5.istex.fr/document/8329DDE00860AE8428688ABEF4A21467FA942225/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B38</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B38</idno><idno type="wicri:Area/Istex/Curation">001B38</idno><idno type="wicri:Area/Istex/Checkpoint">002771</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002771</idno><idno type="wicri:doubleKey">0196-9781:1980:Jolicoeur F:influence:of:substance</idno><idno type="wicri:Area/Main/Merge">005C24</idno><idno type="wicri:Area/Main/Curation">005210</idno><idno type="wicri:Area/Main/Exploration">005210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Influence of substance P on the behavioral changes induced by haloperidol in rats</title><author><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="Francois B." last="Jolicoeur">Francois B. Jolicoeur</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurobiology</wicri:regionArea></affiliation></author><author><name sortKey="Rondeau, Daniel B" sort="Rondeau, Daniel B" uniqKey="Rondeau D" first="Daniel B." last="Rondeau">Daniel B. Rondeau</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurobiology</wicri:regionArea></affiliation></author><author><name sortKey="Belanger, Ferdinand" sort="Belanger, Ferdinand" uniqKey="Belanger F" first="Ferdinand" last="Belanger">Ferdinand Belanger</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurobiology</wicri:regionArea></affiliation></author><author><name sortKey="Fouriezos, George" sort="Fouriezos, George" uniqKey="Fouriezos G" first="George" last="Fouriezos">George Fouriezos</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurobiology</wicri:regionArea></affiliation></author><author><name sortKey="Barbeau, Andre" sort="Barbeau, Andre" uniqKey="Barbeau A" first="André" last="Barbeau">André Barbeau</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurobiology</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Peptides</title><title level="j" type="abbrev">PEP</title><idno type="ISSN">0196-9781</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1980">1980</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page" to="107">107</biblScope></imprint><idno type="ISSN">0196-9781</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0196-9781</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Locomotor activity and grooming behavior of rats were recorded for a period of 30 min following intraventricular injections of substance P(SP) in doses of 0.60 and 2.50 μg/rat. The lower dose of the peptide significantly increased locomotion for 10 min and time spent grooming for 25 min. The effects of the same two doses of SP on the hypokinesia induced by various pharmacological treatments modifying catecholaminergic systems were then examined. SP did not affect the behavioral depression produced by α-methyl-para-tyrosine (250 mg/kg), FLA-63 (25 mg/kg) and phenoxybenzamine (20 mg/kg). However, SP, in dose of 0.60 μg/rat, systematically reversed the decrease in locomotor activity induced by a relatively small dose of haloperidol, 0.1 mg/kg. The same dose of the peptide significantly counteracted the rigidity but not the hypokinesia and the catalepsy resulting from the previous administration of a higher dose of haloperidol, 3 mg/kg. The results support the hypothesis that SP may exert direct or indirect functions in motor behavior, possibly via a modulatory action on brain dopaminergic systems.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Jolicoeur, Francois B" sort="Jolicoeur, Francois B" uniqKey="Jolicoeur F" first="Francois B." last="Jolicoeur">Francois B. Jolicoeur</name></noRegion><name sortKey="Barbeau, Andre" sort="Barbeau, Andre" uniqKey="Barbeau A" first="André" last="Barbeau">André Barbeau</name><name sortKey="Belanger, Ferdinand" sort="Belanger, Ferdinand" uniqKey="Belanger F" first="Ferdinand" last="Belanger">Ferdinand Belanger</name><name sortKey="Fouriezos, George" sort="Fouriezos, George" uniqKey="Fouriezos G" first="George" last="Fouriezos">George Fouriezos</name><name sortKey="Rondeau, Daniel B" sort="Rondeau, Daniel B" uniqKey="Rondeau D" first="Daniel B." last="Rondeau">Daniel B. Rondeau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005210 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005210 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:8329DDE00860AE8428688ABEF4A21467FA942225
|texte= Influence of substance P on the behavioral changes induced by haloperidol in rats
}}
| This area was generated with Dilib version V0.6.29. |  |